Metastatic heterogeneity in pancreatic cancer: mechanisms and opportunities for targeted intervention. Maddipati R, 2025 Jul J Clin Invest 14 135 e191943

Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma. Safari M, Scotto L, Basseville A, Litman T, Xue H, Petrukhin L, Zhou P, Remotti HE, Ku A, Morales DV, Damoci C, Zhu M, Maddipati R, Hull KG, Robey RW, Olive KP, Fojo T, Romo D, Bates SE, 2025 Oct Drug Resist Updat 84 101312

Ablative Radiation Therapy in Oligometastatic Pancreatic Cancer to Delay Polyprogression, Limit Chemotherapy, and Improve Outcomes. Elamir AM, Karalis JD, Sanford NN, Polanco PM, Folkert MR, Porembka MR, Kazmi SA, Maddipati R, Zeh HJ, Timmerman RD, Zhang S, Ligorio M, Beg MS, Aguilera TA, 2022 Jul Int J Radiat Oncol Biol Phys 4 114 792-802

Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer. Huang H, Wang Z, Zhang Y, Pradhan RN, Ganguly D, Chandra R, Murimwa G, Wright S, Gu X, Maddipati R, Müller S, Turley SJ, Brekken RA, 2022 May Cancer Cell 6 40 656-673.e7

MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma. Maddipati R, Norgard RJ, Baslan T, Rathi KS, Zhang A, Saeid A, Higashihara T, Wu F, Kumar A, Annamalai V, Bhattacharya S, Raman P, Adkisson CA, Pitarresi JR, Wengyn MD, Yamazoe T, Li J, Balli D, LaRiviere MJ, Ngo TC, Folkert IW, Millstein ID, Bermeo J, Carpenter EL, McAuliffe JC, Oktay MH, Brekken RA, Lowe SW, Iacobuzio-Donahue CA, Notta F, Stanger BZ, 2022 Feb Cancer Discov 2 12 542-561

APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis. Wörmann SM, Zhang A, Thege FI, Cowan RW, Rupani DN, Wang R, Manning SL, Gates C, Wu W, Levin-Klein R, Rajapakshe KI, Yu M, Multani AS, Kang Y, Taniguchi CM, Schlacher K, Bellin MD, Katz MHG, Kim MP, Fleming JB, Gallinger S, Maddipati R, Harris RS, Notta F, Ross SR, Maitra A, Rhim AD, 2021 Dec Nat Cancer 12 2 1338-1356

Calcium signaling induces a partial EMT. Norgard RJ, Pitarresi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Rosario-Berrios DN, Kim IK, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P, Jolly MK, Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ, 2021 Jul EMBO Rep 9 22 e51872

Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment. Ganguly D, Chandra R, Karalis J, Teke M, Aguilera T, Maddipati R, Wachsmann MB, Ghersi D, Siravegna G, Zeh HJ, Brekken R, Ting DT, Ligorio M, 2020 Sep Cancers (Basel) 9 12 2652

Pancreatic cancer survival analysis defines a signature that predicts outcome. Raman P, Maddipati R, Lim KH, Tozeren A, 2018 Aug PLoS One 8 13 e0201751

Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Reichert M, Bakir B, Moreira L, Pitarresi JR, Feldmann K, Simon L, Suzuki K, Maddipati R, Rhim AD, Schlitter AM, Kriegsmann M, Weichert W, Wirth M, Schuck K, Schneider G, Saur D, Reynolds AB, Klein-Szanto AJ, Pehlivanoglu B, Memis B, Adsay NV, Rustgi AK, 2018 Jun Dev Cell 6 45 696-711.e8

EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration. Aiello NM, Maddipati R, Norgard RJ, Balli D, Li J, Yuan S, Yamazoe T, Black T, Sahmoud A, Furth EE, Bar-Sagi D, Stanger BZ, 2018 Jun Dev Cell 6 45 681-695.e4

KLF4 Initiates Acinar Cell Reprogramming and Is Essential for the Early Stages of Pancreatic Carcinogenesis. Maddipati R, Katz JP, 2016 Mar Cancer Cell 3 29 247-248

Pancreatic Cancer Metastases Harbor Evidence of Polyclonality. Maddipati R, Stanger BZ, 2015 Oct Cancer Discov 10 5 1086-97

Liver and Pancreas: Mechanisms of Development and Size Control. Maddipati R, Stanger BZ, 2014 In: Stem Cells: From Basic Research to Therapy, Calegari F, Waskow C, eds. Science Publishers

Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gao T, Zhou D, Yang C, Singh T, Penzo-Méndez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ, 2013 Jun Gastroenterology 7 144 1543-53

Robust cellular reprogramming occurs spontaneously during liver regeneration. Yanger K, Zong Y, Maggs LR, Shapira SN, Maddipati R, Aiello NM, Thung SN, Wells RG, Greenbaum LE, Stanger BZ, 2013 Apr Genes Dev 7 27 719-24

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). Bulua AC, Simon A, Maddipati R, Pelletier M, Park H, Kim KY, Sack MN, Kastner DL, Siegel RM, 2011 Mar J Exp Med 3 208 519-33

Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome. Simon A, Park H, Maddipati R, Lobito AA, Bulua AC, Jackson AJ, Chae JJ, Ettinger R, de Koning HD, Cruz AC, Kastner DL, Komarow H, Siegel RM, 2010 May Proc Natl Acad Sci U S A 21 107 9801-6

Peptide-conjugated quantum dots activate neuronal receptors and initiate downstream signaling of neurite growth. Vu TQ, Maddipati R, Blute TA, Nehilla BJ, Nusblat L, Desai TA, 2005 Apr Nano Lett 4 5 603-7