TARGETING THE DIVERSE LANDSCAPE OF TUMORS AND METASTASIS
Tumor Heterogeneity and Pancreatic Cancer Research Program
UT Southwestern Medical Center
Department of Internal Medicine
Division of Digestive and Liver Diseases
Children’s Research Institute
Harold C. Simmons Comprehensive Cancer Center
Hamon Center for Therapeutic Oncology Research
Using novel multi-omics approaches and model systems to treat pancreatic cancer
Tumors are diverse eco-systems comprised of many different cell types that function together to drive progression and therapy resistance. The Maddipati laboratory is broadly interested in understanding how this cellular and molecular heterogeneity develops and impacts on tumor formation, metastatic progression, and therapy. Our laboratory combines fundamental developmental biology tools, such as lineage tracing in genetically engineered mouse models, with bioinformatic approaches, CRISPR screening tools, bioengineered systems, and clinical specimens to study the functional consequences of tumor heterogeneity in pancreatic cancer.
Ravi Maddipati | Department of internal medicine
6000 Harry Hines Blvd., NB8.221
Dallas, Tx 75390
UTSouthwestern Medical Center
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